Host: Katherine Linton.  Featured guests: Alex Sichel, Peter Frechette, Juanita Owens, Irene Farerra, Rob Epstein, Jeffrey Friedman.

Summary: The episode begins with a segment about funding challenges for the AIDS charities, Food & Friends and the Whitman-Walker Clinic. The Out Artists Speak Out segment features Alex Sichel and Peter Frechette, followed by a profile of activist Juanita Owens. The In the Arts segment covers HomoCorps at CBGB, Irene Farrera with Sounds of Venezuela, and Rob Epstein and Jeffrey Friedman's Third Reich documentary Paragraph 175. The Romaine Brooks segment focuses on the artist's retrospective in Washington, D.C. The indie films, Punks and Chutney Popcorn, are spotlighted, and the In the News segment covers the Stop Dr. Laura! protest and the GLBT Christian Conference in DeKalb, Illinois. The episode also features a rebroadcast of the Rainbow Support Group segment from episode 904.

Host: Bill Brochtrup.  Featured guests: Phill Wilson, John Dugdale, Harvey Fierstein, Pamela Sneed, Alan Menken, Kristen Johnston.

Summary: This episode is a rebroadcast of episode 1206, originally broadcast March 2003. The episode primarily focuses on art, science, culture and activism related to AIDS.

Note: Some audio content removed due to copyright restrictions.
54:39 - 56:06: Pet Shop Boys, "Being Boring"

Host: Bill Brochtrup.  Featured guests: Juan Carlos Zaldívar, Harvey Fierstein, Barbara Gittings, Rosie O'Donnell.

Summary: This episode is a reversion featuring segments from previous episodes as well as new segments. Excerpts from episodes 801, 805, 1301, 1302 and 1305 cover such topics as lesbian Muslims, aging with AIDS, Project YES, same-sex marriage in Hawaii, and the documentary, 90 Miles. Harvey Fierstein's Out Takes segment is titled "Catch Me If You Want." Barbara Gittings and Rosie O'Donnell provide PSAs during the episode.

Host: Sharon Gless.  Featured guests: Howard Grossman, Ron Valdiserri, Larry Kramer.

Summary: The final episode of season 13 begins with a segment examining how perceptions of AIDS have changed over time, the seriousness of the crisis and new HIV treatments. The next segment is about methamphetamine use in the LGBT community, particularly relating to the increased risk of contracting HIV. Another segment spotlights homeless LGBT youth in Los Angeles and New York City, highlighting their struggles and HIV risk. The Real to Reel segment is about Of Men and Gods, a Haitian documentary that explores the nature of homosexual orientation within the context of voodoo and the shadow of AIDS.

Host: Sharon Gless.  Featured guests: Howard Grossman, Ron Valdiserri, Larry Kramer.

Summary: This episode is a rebroadcast of episode 1412, which originally broadcast September 2005. It begins with a segment examining how perceptions of AIDS have changed over time, the seriousness of the crisis and new HIV treatments. The next segment is about methamphetamine use in the LGBT community, particularly relating to the increased risk of contracting HIV. Another segment spotlights homeless LGBT youth in Los Angeles and New York City, highlighting their struggles and HIV risk. The Real to Reel segment is about Of Men and Gods, a Haitian documentary that explores the nature of homosexual orientation within the context of voodoo and the shadow of AIDS.

Host: Michael Billy. Featured guests: Camille Paglia, Sandra Bernhard, Richard Kim, Marjorie Hill, Wilson Cruz.

Summary:  This episode consists of three installments of the A conversation with… segment. In the first segment, Camille Paglia and Sandra Bernhard discuss the sexuality in their work, the many faces of lesbian identity, and the influence of the gay male sensibility in contemporary art and culture. In the next segment, associate editor of The Nation Richard Kim sits down with host Michael Billy to look at issues in the LGBT community. In the final segment, CEO of Gay Men's Health Crisis Dr. Marjorie Hill speaks with Wilson Cruz about the AIDS epidemic and the continuing importance of education in confronting the disease and LGBT stereotypes.

Summary: The episode begins with a segment about Messengers of Hope, a gospel choir from Oakland, California that engages African American churches in conversation about HIV and AIDS. The next segment is about federal protection laws against workplace discrimination and the progress of LGBT people in corporate America.